Acetylcholine functionally reorganizes neocortical microcircuits
نویسندگان
چکیده
منابع مشابه
Acetylcholine functionally reorganizes neocortical microcircuits.
Sensory information is processed and transmitted through the synaptic structure of local cortical circuits, but it is unclear how modulation of this architecture influences the cortical representation of sensory stimuli. Acetylcholine (ACh) promotes attention and arousal and is thought to increase the signal-to-noise ratio of sensory input in primary sensory cortices. Using high-speed two-photo...
متن کاملNeocortical Microcircuits 1 Abbreviated title : Acetylcholine Functionally
41 Sensory information is processed and transmitted through the synaptic structure of local cortical 42 circuits, but it is unclear how modulation of this architecture influences the cortical 43 representation of sensory stimuli. Acetylcholine (ACh) promotes attention and arousal and is 44 thought to increase the signal-to-noise ratio of sensory input in primary sensory cortices. Using 45 high-...
متن کاملAcetylcholine excites neocortical
21 The neuromodulator acetylcholine shapes neocortical function during sensory 22 perception, motor control, arousal, attention, learning and memory. Here we investigate 23 the mechanisms by which ACh affects neocortical pyramidal neurons in adult mice. 24 Stimulation of cholinergic axons activated muscarinic and nicotinic ACh receptors on 25 pyramidal neurons in all cortical layers and in mult...
متن کاملProbabilistic inference of short-term synaptic plasticity in neocortical microcircuits
Short-term synaptic plasticity is highly diverse across brain area, cortical layer, cell type, and developmental stage. Since short-term plasticity (STP) strongly shapes neural dynamics, this diversity suggests a specific and essential role in neural information processing. Therefore, a correct characterization of short-term synaptic plasticity is an important step towards understanding and mod...
متن کاملTarget-Specific Expression of Presynaptic NMDA Receptors in Neocortical Microcircuits
Traditionally, NMDA receptors are located postsynaptically; yet, putatively presynaptic NMDA receptors (preNMDARs) have been reported. Although implicated in controlling synaptic plasticity, their function is not well understood and their expression patterns are debated. We demonstrate that, in layer 5 of developing mouse visual cortex, preNMDARs specifically control synaptic transmission at py...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2014
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00071.2014